Hiroshi Maeda, Alexander Kabanov, Kazunori Kataoka, Teruo's Polymer Drugs in the Clinical Stage: Advantages and PDF

By Hiroshi Maeda, Alexander Kabanov, Kazunori Kataoka, Teruo Okano

ISBN-10: 0306474719

ISBN-13: 9780306474712

Proceedings of the foreign Symposium on Polymer Therapeutics - fresh growth in Clinics and destiny clients, held July 13-14, 2001, in Nara, Japan.

The know-how of polymer technology has built significantly prior to now half-century, and this quantity describes many of the features of this know-how that would have a good effect sooner or later. between those advances, for instance, are gene supply to express affliction websites and service polymers that reply to a stimulus or specific setting. melanoma special drug supply is one other centred sector of this quantity end result of the very important nature of EPR-effect of polymer medicines in tumor. incorporated are discussions of as many examples as attainable of polymer medications that experience accomplished, or are on the subject of medical use. the idea that of "Polymer medicinal drugs" here's constrained to basically injectable and water-soluble brokers, even if additionally coated are a few medicinal drugs in micellar shape or liposomes.

This booklet is meant for college kids and researchers within the box of pharmacology who've specific pursuits in drug supply, focusing on, and formula, in addition to for clinicians reminiscent of oncologists who're attracted to the sector. those that paintings at regulatory firms also needs to bear in mind such that medicines with nice power are being built and may be useful to many sufferers, in addition to to medical health insurance firms as a result of greater price effectiveness.

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1991, Kinin-generating cascade in advanced cancer patients and in vitro study. Jpn. J. Cancer Res. 82: 732-741. , 1998, Modulation of enhanced vascular permeability in tumors by bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger. Cancer Res. 58: 159-165. , 1994, Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both nitric oxide scavenger and nitric oxide synthase inhibitor. Jpn. J. Cancer Res. 85: 331 -334. , 1996, Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth.

128. , S. Li, R. Mandeville, A. Kabanov and V. Alakhov, 1996, Hypersensitizing effect of pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multiple drug- resistant cells. Cancer Res. 56:3626-3629. 129. , P. Santoro and M. Pedrani, 1999, Quality and functionality of excipients. Farmaco 54:1-14. 130. , 1981, The adjuvant activity of fatty acid esters. The role of acyl chain length and degree of saturation. Immunology 44:187-192. 131. , M. Olsen and S. Buynitzky, 1991, Adjuvant activity of non-ionic block copolymers.

In normal tissues, however, the lipid contrast medium Lipiodol and lipids as well as plasma proteins and macromolecules are cleared from the reticuloendothelial/ lymphatic system 7, 26-30. To describe this phenomenon related to the fate of macromolecular drugs and lipids in solid tumor, we coined the term EPR (enhanced permeability and retention) effect in 1984 3, 26, 30, 31. According to the EPR concept, biocompatible macromolecules accumulate at much higher (> 6 fold more) concentrations in tumor tissues than in normal tissues or organs, even higher than those in plasma26, 27, 30, 31.

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Polymer Drugs in the Clinical Stage: Advantages and Prospects by Hiroshi Maeda, Alexander Kabanov, Kazunori Kataoka, Teruo Okano


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