By Hiroshi Maeda, Alexander Kabanov, Kazunori Kataoka, Teruo Okano
Proceedings of the foreign Symposium on Polymer Therapeutics - fresh growth in Clinics and destiny clients, held July 13-14, 2001, in Nara, Japan.
The know-how of polymer technology has built significantly prior to now half-century, and this quantity describes many of the features of this know-how that would have a good effect sooner or later. between those advances, for instance, are gene supply to express affliction websites and service polymers that reply to a stimulus or specific setting. melanoma special drug supply is one other centred sector of this quantity end result of the very important nature of EPR-effect of polymer medicines in tumor. incorporated are discussions of as many examples as attainable of polymer medications that experience accomplished, or are on the subject of medical use. the idea that of "Polymer medicinal drugs" here's constrained to basically injectable and water-soluble brokers, even if additionally coated are a few medicinal drugs in micellar shape or liposomes.
This booklet is meant for college kids and researchers within the box of pharmacology who've specific pursuits in drug supply, focusing on, and formula, in addition to for clinicians reminiscent of oncologists who're attracted to the sector. those that paintings at regulatory firms also needs to bear in mind such that medicines with nice power are being built and may be useful to many sufferers, in addition to to medical health insurance firms as a result of greater price effectiveness.
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Extra info for Polymer Drugs in the Clinical Stage: Advantages and Prospects
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In normal tissues, however, the lipid contrast medium Lipiodol and lipids as well as plasma proteins and macromolecules are cleared from the reticuloendothelial/ lymphatic system 7, 26-30. To describe this phenomenon related to the fate of macromolecular drugs and lipids in solid tumor, we coined the term EPR (enhanced permeability and retention) effect in 1984 3, 26, 30, 31. According to the EPR concept, biocompatible macromolecules accumulate at much higher (> 6 fold more) concentrations in tumor tissues than in normal tissues or organs, even higher than those in plasma26, 27, 30, 31.
Polymer Drugs in the Clinical Stage: Advantages and Prospects by Hiroshi Maeda, Alexander Kabanov, Kazunori Kataoka, Teruo Okano