By James M. Croop (auth.), Martin Clynes (eds.)
This e-book is an up to date overview of present wisdom within the box of a number of drug resistance in human melanoma. The literature as much as the center of 1993 is surveyed in professional chapters written by means of diversified specialists. themes coated comprise the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; substitute delivery proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; mobile versions for MDR in strong tumours and haemopoietic tumours; immunochemical and molecular organic options for detection of MDR-related gene expression; and scientific and pharmacological thoughts to avoid resistance. The e-book brings jointly a brand new mix of ways to this severe medical challenge.
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Extra info for Multiple Drug Resistance in Cancer: Cellular, Molecular and Clinical Approaches
1989). , 1987) are comprised of four similar groups each including six transmembrane spanning domains. These hydrophobic regions are interspersed with cytoplasmic domains predicting a structure not dissimilar to a pair of linked P-glycoproteins. The P-glycoprotein, however, does not display significant homology at the amino acid level to these transport proteins and channels. Whether the lack of amino acid homology with structural homology represents divergence from the ancestral origins of the transport proteins or convergence to motifs which perform similar functional activities is unknown.
Science 232: 751-755. Sehested M, Simpson D, Skovsgaard T and Buhl-Ienson P (1989) Freeze-fracture study of plasma membranes in wild type and daunorubicin-resistant Ehrlich ascites tumor and P388 leukemia cells. Virchows Arch [b] 56: 327-335. Shen DW, Fojo A, Chin JE, Roninson IB, Richert N, Pastan I and Gottesman MM (1986) Human muItidrug-resistant cell lines: increased mdrl expression can precede gene amplification. Science 232: 643-645. Skach WR, Calayag MC and Lingappa VR (1993) Evidence of an alternative model of human P glycoprotein structure and biogenesis.
1988). Despite slightly varying cross resistance patterns, most of these cultured multidrug resistant cell lines produce elevated levels of P-glycoprotein as first described by Juliano and Ling (1976). Thus, these multidrug resistant cell lines represent very useful model systems to study various aspects of the P-glycoprotein-mediated mechanism of multidrug resistance. , this volume; Nooter and Sonneveld, this volume). Various drug-sensitive parental cells and their multidrug resistant derivatives have also been used to deter- mine the kinetics of uptake, efflux, and accumulation of drugs, and to analyze the energy requirements of the drug transport process (Michelson, this volume).
Multiple Drug Resistance in Cancer: Cellular, Molecular and Clinical Approaches by James M. Croop (auth.), Martin Clynes (eds.)