By N. G. Conradi (auth.), Prof. Dr. Kurt Jellinger, Prof. Dr. Filippo Gullotta, Prof. Dr. Miroslav Mossakowski (eds.)
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Additional resources for Experimental and Clinical Neuropathology: Proceedings of the First European Neuropathology Meeting, Vienna, May 6–8, 1980
We wish to thank Dr. L. Latzkovits (Dept Experimental Surgery, Univ. Med. School, Szeged) for establishing the cell cultivation in our laboratory. 50 c E x Table 1. 35 b a For this purpose the lines and curves of neuronal processes were followed by a map curvimeter on randomly taken phase contrast photomicrographs. Number of experiments: 30 for each value. 001). 46 c 2: 25 ec. J o E c 0 A B c Fig. 2. Li uptake by different cultures of dissociated brain cells. A, neuronal; B, mixed neuronal-glial; and C, glial cell cultures.
1). Among the regions studied, the hippocampus showed the most severe dendritic change. The long-term (1 year) small-dose Li administration apparently did not cause any fme structural alteration in the rat brain when compared to the controls. Concerning the results obtained in nerve cell cultures, a significant decrease was found in dendro-axonal network of neurons after Li (10 mM) exposure (Table 1). When using brain cell cultures of different proportion of neuronal and glial elements, it was observed that neuron-enriched cultures showed higher Li uptake in comparison with the values found in cultures of predominantly glial cells (Fig.
4. e. from the same analysed axonal point. All values from axons of the sciatic nerve 36 h after crush. At left from arrows: normal range ofK and Cl, low Na. Between arrows: low K, increasing Na, unchanged Cl. g. dissolution or agglomeration of neurofilaments and/or microtubules. Some fibers are distorted or collapsed, but desintegration of the myelin sheaths has not yet taken place. The X-ray spectra ofaxons from the same nerve 36 hours after crush differ markedly from the spectra from normal fibers as well as from fibers 18 hours after crush (Fig.
Experimental and Clinical Neuropathology: Proceedings of the First European Neuropathology Meeting, Vienna, May 6–8, 1980 by N. G. Conradi (auth.), Prof. Dr. Kurt Jellinger, Prof. Dr. Filippo Gullotta, Prof. Dr. Miroslav Mossakowski (eds.)