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Extra resources for Immunodeficient rodents: a guide to their immunobiology, husbandry, and use

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Mutations The determination of cause-and-effect relationships between normal and abnormal physiologic processes is often complex, and specific experimental techniques are required to study them. One effective technique is to study systems in which normal function has been altered by mutation, a spontaneous heritable change that results in some measurable change in the structure or function of the organism. The optimal use of the mutant models described in this guide requires an understanding of basic genetic principles.

Jaworski, Monsanto Company, St. Louis, Missouri Simon A. Levin, Ecosystems Research Center, Cornell University, Ithaca, New York Harold A. Mooney, Stanford University Page vi Steven P. Pakes, University of Texas Southwestern Medical Center, Dallas Joseph E. Rall, National Institutes of Health, Bethesda, Maryland Richard D. Remington, University of Iowa Paul G. Risser, University of New Mexico, Albuquerque Richard B. Setlow, Brookhaven National Laboratory, Upton, New York Torsten N. " These mice, which have thymic aplasia and a developmental defect in hair growth, are difficult to maintain because of their severely compromised T-cell immunity and, consequently, their lack of resistance to many microbial diseases.

Dr. Robert M. White is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and upon its own initiative to identify issues of medical care, research, and education.

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Immunodeficient rodents: a guide to their immunobiology, husbandry, and use by Institute of Laboratory Animal Resources

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