Roland T. Jung's Endocrine Problems in Cancer. Molecular Basis and Clinical PDF

By Roland T. Jung

ISBN-10: 0433302771

ISBN-13: 9780433302773

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Extra resources for Endocrine Problems in Cancer. Molecular Basis and Clinical Management

Example text

J. Ponder Genetic Problems of Endocrine Significance INTRODUCTION Genetic Contribution to Cancer Incidence Cancer has not generally been regarded as a disease with a major inherited component. Cancer syndromes in which an inherited influence is suf­ ficiently strong to be clinically evident account for only a small minority of cancer incidence, and the endocrine tumours to be discussed in this chapter will necessarily be drawn from this small minority. It is as well to realise at the outset, however, that this view of the role of inherited factors in cancer incidence is almost certainly too restricted.

1961). Am. J. Obst. Gynaecol; 82: 631-7. W. (1979). Br. Med. J; 1: 487. E. (1972). Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes. Science; 177: 793-5. Endocrine Markers in Cancer 37 Imura H. (1980). Ectopie hormone production viewed as an abnormality in regulation of gene expression. Adv. Cancer Res; 33: 39-75. R. (1980). A C T H secreting medullary carcinoma of the thyroid: Monitoring of clinical course with calcitonin and cortisol assays and immunohistochemical studies.

The spectrum of tumours varies in different individuals with the familial form, as does the age at presentation. It is thus a complex problem to decide, when confronted with a patient in whom one of the tumours has been diagnosed, how energetically to set about screening that individual for the presence of the other possible tumours in the syndrome, and whether to screen other family members. There is no correct answer to this question. A careful family history is essential (but often neglected).

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Endocrine Problems in Cancer. Molecular Basis and Clinical Management by Roland T. Jung


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