By V.E. Andreucci, Antonia Dal Canton
The want for sufficient capability through which to enhance urine output is particularly outdated. Even within the "Scuola Salernitana", the oldest medieval clinical tuition in Western Europe, approximately one thousand years in the past it was once taught the best way to enhance urine output. The checklist of identified "diuretica" integrated herbs, crops, roots, greens, particularly asparagus, fennel and carrot. the 1st diuretic medicinal drugs, even though, have been mercurial compounds. therefore, calomel, mercurous chloride, was once at the start used as a diuretic within the 16th century through Paracelsus, being one of many elements of the so-called "Guy's medical institution pill". yet calomel had a cathartic impression in order that it was once changed by way of natural mercurial compounds. those diuretics have been truly poisonous. After the invention of the automobile bonic anhydrase, within the early Thirties, and the advent of sulfanilamide as a chemotherapeutic agent, it used to be saw that this drug was once inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby inflicting metabolic acidosis; urine output, in spite of the fact that, looked as if it would elevate. next experiences resulted in the synthesis of stronger analogs, specifically acetazolamide. stories on motor vehicle bonic anhydrase inhibitors ended in the synthesis of benzothiadiazides which disclosed less inactivating motion on carbonic anhydrase and lots more and plenty extra diuretic impression via an inhibition of tubular delivery of sodium and chloride. Chlorothiazide used to be the 1st member of this type of diuretics. Thiazides are nonetheless utilized in scientific practice.
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Extra info for Diuretics: Basic, Pharmacological, and Clinical Aspects: Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986
Dept. de Investig. Cardiovascular Fundacion Procardias Montevideo, Uruguai Riera 1. Hospital de Bellvtige "Princeps d'Espanya" Barcelona, Spain Righetto F. Department of Nephrology and Dialysis Umberto I Hospital Venice-Mestre, Italy Risler T. Department of Internal Medicine University of Tubingen Tubigen, FRG Rizzelli S. Frazzi" Hospital Leece, Italy Rodico 1. Service of Nephrology 1 Octubre Hospital Madrid, Spain Rodrigue F. IHB Research Labs. Le Plessis, France Rolando B. Department of Nephrology University of Turin Turin, Italy Romano C.
Department of Clinical Therapeutics University of Athens "Alexandra" Hospital Athens, Greece Mazzia G. T. University Department of Medicine Gardiner Institute Western Infirmary Glasgow, Scotland Memoli B. Department of Nephrology II Faculty of Medicine University of Naples Naples, Italy Menegazzi M. Clinica Medica University of Verona Medical School Policlinico Verona, Italy Messa M. Division of Nephrology City Hospital Udine, Italy Messa P. Division of Nephrology City Hospital Udine, Italy xlii Messina A.
8) • A special class of medications were the so-called "diuretica forinseca", the diuretics for external use. These medications were either applied on the skin or injected through the urethra, in the latter case mainly to solve stones. " (7) • 1. Pazzini A. Pagine di Storia della Scienza e della Tecnica. 10:1-13, 1958. 2. Fontana E. II Libro delle Urine di Isacco l'Ebreo tradotto dall'Arabo in Latino da Costantino l'Africano. In: Scienza Vete rum (Ed. G. Del Guerra) , Pisa, Casa Editrice Giardini, 1966.
Diuretics: Basic, Pharmacological, and Clinical Aspects: Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986 by V.E. Andreucci, Antonia Dal Canton