Download PDF by Nicole M. Lauzon, Firoz Mian, Ali A. Ashkar (auth.), John D.: Current Topics in Innate Immunity

By Nicole M. Lauzon, Firoz Mian, Ali A. Ashkar (auth.), John D. Lambris (eds.)

ISBN-10: 038771765X

ISBN-13: 9780387717654

ISBN-10: 0387717676

ISBN-13: 9780387717678

Innate Immunity has lengthy been considered as the non-specific arm of immune reaction, performing instantly and in a established manner, to safeguard the host from infections. within the put up genomic period, our wisdom of the innate immune process is enriched by means of findings at the specificity of innate immune reactions in addition to to novel features that don't strictly correlate with immunological safety and surveillance, immune modulation or irritation. a number of reviews point out that molecules excited by innate immunity exert capabilities which are both extra complicated than formerly notion, or pass way past the innate immune personality of the system.

The creation of high-throughput structures for genome and proteome-wide profiling, including the big quantity of uncooked genetic info that has collected within the databases, have stirred new expectancies in biomedical study. they've got led scientists to revisit tested organic structures from an international and integrative standpoint. Innate Immunity learn is now confronted with the problem of attempting to combine remoted biochemical pathways into advanced gene and protein regulatory circuits. during this recognize, scientists from around the globe convened on the 4th foreign convention on Innate Immunity (June four - nine, 2006), in Corfu, Greece to debate contemporary advances during this quick evolving field.

This quantity represents a suite of issues on normal killer cells, mast cells, phagocytes, toll like receptors, supplement, host safety in vegetation and invertebrates, evasion thoughts of microorganisms, pathophysiology, protein constructions, layout of therapeutics, and experimental methods mentioned in the course of the conference.

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Schematic representation of foreign glycolipids that have been determined in complex with hCD1d. 4) The hydrophobic tail of the glycolipid is linked via an α- or β-anomeric link to a hydrophilic head group. The composition of the head group is a single or multiplelinked sugar moiety with or without modifications. , 2005b). , 2005a) of a glycosphingolipid. Glycosphingolipids with a sphinganine backbone, such as GalA-GSL, lack the 4′-hydroxyl and only make contact with CD1d through the 3′-hydroxyl of the sphinganine backbone.

Becker et al. (2003) first characterized the membrane expression of TLR2 in human NK cells (Becker, Salaiza, Aguirre, Delgado, Carrillo-Carrasco, Kobeh, Ruiz, Cervantes, Torres, Cabrera, Gonzalez, Maldonado and Isibasi 2003). A cell surface-derived protein, LPG, from the obligate intracellular pathogen Leishmania, inhibits IL-12 production from the host macrophages. This parasitederived LPG stimulates human NK cells via TLR2, inducing NF-κB nuclear translocation, TNF-α production and subsequently inducible nitric oxide synthase (iNOS) activation from macrophages, killing the pathogen.

5, 405-411. , Carra, G. and Trinchieri, G. (2002) Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med. 195, 327-333. , Carra, G. and Trinchieri, G. (2005) The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions. J Immunol. 174, 727-734. , Flavell, R. A. and Metcalfe, D. D. (2004) Activation of mast cells by doublestranded RNA: evidence for activation through Toll-like receptor 3.

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Current Topics in Innate Immunity by Nicole M. Lauzon, Firoz Mian, Ali A. Ashkar (auth.), John D. Lambris (eds.)

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