New PDF release: Basic and Clinical Tumor Immunology

By Osias Stutman (auth.), Ronald B. Herberman (eds.)

ISBN-10: 1461338735

ISBN-13: 9781461338734

ISBN-10: 1461338751

ISBN-13: 9781461338758

Where do you start to seem for a up to date, authoritative article at the prognosis or administration of a selected malignancy? The few common onco­ logy textbooks are mostly old-fashioned. unmarried papers in really expert journals are informative yet seldom finished; those are extra usually prelimi­ nary studies on a really restricted variety of sufferers. yes common journals usually post reliable indepth studies of melanoma themes, and released symposium lectures are usually the easiest overviews to be had. regrettably, those reports and vitamins look sporadically, and the reader can by no means make sure while an issue of distinct curiosity can be coated. melanoma therapy and learn is a sequence of authoritative volumes which goal to fulfill this desire. it's an try to determine a severe mass of oncology literature protecting nearly all oncology subject matters, revised usually to maintain the assurance modern, simply to be had on a unmarried library shelf or by means of a unmarried own subscription. we have now approached the matter within the following style. First, via divid­ ing the oncology literature into particular subdivisions similar to lung melanoma, genitourinary melanoma, pediatric oncology, and so forth. moment, via asking eminent specialists in every one of those parts to edit a quantity at the particular subject on an annual or biannual foundation. each one subject and tumor style is roofed in a quantity showing often and predictably, discussing present prognosis, staging, markers, all types of therapy modalities, uncomplicated biology, and more.

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It is quite apparent that nude CBA/H mice treated with anti-mu have a marked increase in lymphoma development (42 %), which is also observed in BALB/c mice (28 %), when compared to controls. 1, is relatively short for lymphoma studies. The first lymphoma in the anti-mu treated mice began to appear at 140 days, which is quite early for this type of tumor. Six of the 18 lymphomas in the anti-mu treated CBA-nudes, studied so far, proved to be surface Ig positive, and also all expressed murine leukemia virus antigens, as was observed by Beatie et al.

The actual incidence was well within the variation range of lymphoma incidences in BALB/c mice, including germ-free animals (see [25, 26, 183] for discussion of this point, with the appropriate references supporting the argument). However, statements such as ' ... a high incidence of lymphoreticular tumors has been observed in congenitally immunodefective germ-free nude mice ... ' [151], citing ref. [23], are quite common in present day literature. 25 An even worse example is found in ref. [184], where it is stated, that, 'The low incidence of spontaneous tumors in congenitally immunodeficient nude mice ...

A subsequent and more detailed paper using similar procedures, unfortunately did not contain data using nude mice [79]. It is not easy to produce at present an explanation of these modest differences in papilloma incidence. However, it is worth mentioning here that technical differences may be important in this type of experiment using skin grafting. 15 mg of methylcholanthrene and full-thickness skin grafts containing the pellet were transplanted; under these conditions tumor development (probably fibrosarcomas) was reduced in the grafted animals.

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Basic and Clinical Tumor Immunology by Osias Stutman (auth.), Ronald B. Herberman (eds.)

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