By C. Wüster, T. Cowell
Complement factor: Hormone examine 2000, Vol. fifty four, No. 1
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Additional info for Analytical Methods in Clinical Osteology: Useful Predictors of Long-Term Outcomes or a Waste of Time and Money? 4th Kigs Kims Expert Meeting on Growth ... Taormina, November (Hormone Research)
C. Wüster Karlstrasse 41 D–65185 Wiesbaden (Germany) Tel. dk Fig. 1. Comparison of the results from two studies assessing the prev- alence of fractures in adults with GHD and the general population [2, 15]. Controls in the study by Wüster et al.  were a cohort of EVOS from Germany; controls in the study by Rosén et al.  were a cohort from the MONICA project in Sweden. Various methods for estimating bone strength, other than BMD measurement, are available, but most of these methods have not been used in patients with GHD.
These mechanisms interact with bone in a way that no single kind of cell can. Modelling, rather than osteoblasts alone, provides nature’s main way of increasing bone strength, whereas BMU-based remodelling provides nature’s main way of conserving bone or removing bone that is not needed mechanically [15, 36, 37]. Directly or indirectly, special bone strain threshold ranges help to control both mechanisms [15, 36–39]. Where bone strains exceed the higher modelling threshold range (the minimum effective strain [MESm] range or equivalent stimulus), modelling is activated, increasing bone strength and ‘mass’.
These mechanisms work independently, although both seem to use the same kinds of osteoblasts and osteoclasts. 38 Horm Res 2000;54(suppl 1):36–43 An analogy may help to understand the roles of these thresholds. Let heat = whole-bone strength (where = means ‘be like’), let modelling = heating, let remodelling = cooling, and let thermostats = bone strain thresholds. A thermostat can make a house furnace add heat when there is not enough, but it turns the furnace off when there is enough or too much heat.
Analytical Methods in Clinical Osteology: Useful Predictors of Long-Term Outcomes or a Waste of Time and Money? 4th Kigs Kims Expert Meeting on Growth ... Taormina, November (Hormone Research) by C. Wüster, T. Cowell