By Francesco Collamati
This thesis specializes in a unique radio-guided surgical procedure approach for whole tumor resections. It describes all features of the intraoperative probe, in addition to trying out and simulation of the unconventional strategy. The presentation develops the method from the preliminary thought to real looking feasibility reports which have been the topic of a statement of the yankee Society of Nuclear drugs. only a yr after finishing this paintings, the method has now been confirmed for the 1st time on a meningioma sufferer, confirming the entire predictions made during this thesis.
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Extra info for An Intraoperative Beta−Probe for Cancer Surgery
Ann. Nucl. Med. 19(1), 23–28 (2005) 17. S. Bonzom, L. Ménard, S. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, An intraoperative beta probe dedicated to glioma surgery : design and feasibility study. IEEE Trans. Nucl. Sci. 54(30), 30–41 (2007) 18 1 Introduction to Radioguided Surgery 18. F. Bogalhas, Y. -A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, L. Ménard, Development of a positron probe for localization and excision of brain tumours during surgery. Phys. Med. Biol.
1. To take into account the background contribution coming from the uptake of nearby healthy tissue, a FLUKA simulation was used. In this simulation, performed using the parameters obtained in Sect. 4, I tested the response of the probe over a large (some cm in diameter and height, Fig. 2 First Probe Prototypes 41 Fig. 2 2 >10 4 4 The probe was tested on phantoms sized as possible tumor residuals of interest, filled with 90 Y in saline solution to simulate the situation after bulk meningioma removal.
E. the grade of gray in a image) and the material is performed by means of two text files. A first one is a table that assigns to each HU value a tissue density, while a second file assigns to each HU interval a material. This is a significantly nontrivial conversion, due to very large variations between patients and body zones. ). The result of such importation process are showed in Fig. 1. 24 2 The FLUKA Monte Carlo Code Fig. 1 Result of the importation of CT dicom files in FLUKA. inp. ; Initialization of the random number sequence; Starting signal and number of requested histories.
An Intraoperative Beta−Probe for Cancer Surgery by Francesco Collamati