By David H. Ingbar, Joseph M. Lasnier (auth.), Sadis Matalon, Jacob Lasha Sznajder (eds.)
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Extra info for Acute Respiratory Distress Syndrome: Cellular and Molecular Mechanisms and Clinical Management
14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 1. M. Clark, C. J. Lamberstein, Pharmacol. Rev. 23,37 (1971). H. , Chest 97, 1176 (1990). 1. P. Mitchel, D. Schuller, F. S. Calandrino, D. P. Schuster, Am. Rev. Respir. Dis. 145,990 (1992). 1. I. Sznajder, L. D. H. Wood, Chest 100, 890 (1991). A. E. Taylor, Or. Res. 49(3),557 (1981). Y. , J. Clin. Invest 79, 335 (1987). R. M. Effros, G. R. Mason, J. Hukkanen, P. Silverman, J. Appl. Physiol. 66,906 (1989). B. Goodman, R. Fleisher, E. D. Crandall, Am. J. Physiol.
The changes shown in these studies of lymphatics during pulmonary edema and its resolution show the great capacity of the lymphatic system to accommodate excess fluid. Lymph flow increases with pulmonary injury and the increased lymph flow and increased absorptive functions are major protective mechanisms aga inst pulmonary edema. SUMMARY • Lung lymphatics can be cast by injecting a resin through the vasculature or airways if the alveolar epithelium is damaged as occurs in animals exposed to hyperoxia.
1. I. Sznajder, W. G. Olivera, K. M. Ridge, D. H. Rutschman, Am. J. Resp. Crit. Care Med. 151,1519 (1995). J. F. , Am. J. Physiol. 266, L30 (1994). THE ROLE OF LUNG LYMPHATICS IN PULMONARY EDEMA CLEARANCE Kyriakos D. Chainis' , Karen M. Ridge2, Jacob I. Sznajder', Dean Schraufnagel 3 'Corfu General Hospital, Pulmonary Department, Corfu, Greece Reese Hospital and Med ical Center, Pulmonary and Critical Care Medicine, Chicago IL 60616 3Unversity of Illinois at Chicago, Pulmonary and Critical Care Medicine, Chicago, IL 60680 2Michael INTRODUCTION The acute respiratory distress syndrome (ARD S) is characterized by damage to the alveolar endothelial-epithelial barrier with increased permeability' resulting in influx of fluid from the circulation into the lung.
Acute Respiratory Distress Syndrome: Cellular and Molecular Mechanisms and Clinical Management by David H. Ingbar, Joseph M. Lasnier (auth.), Sadis Matalon, Jacob Lasha Sznajder (eds.)