Acromegaly: A Century of Scientific and Clinical Progress by Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins PDF

By Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)

ISBN-10: 1461290643

ISBN-13: 9781461290643

ISBN-10: 1461319137

ISBN-13: 9781461319139

The manuscripts during this quantity have been contributed by way of the audio system invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The assembly used to be geared up to commemorate the outline of acromegaly via the French health care provider Pierre Marie, in 1886. The individuals of the medical Committee spent many hours supporting us in making sure a great assembly. The aid of Serono Symposia, united states in all stages of the making plans and execution of the assembly was once basically favored and was once hugely expert. exact acceptance roust be prolonged to Professor Roger Guillemin of the Salk Institute, whosp curiosity in clinical historical past led him to dedicate loads of time and private fee in acquiring information regarding the lifetime of Pierre Marie. Dr. GuilIemin's presentation at the existence and occasions of Marie used to be a rare evaluation of the cultural, social, and clinical backgrounds during which Marie got here to explain the affliction, acromegaly. Dr. Guillemin' s findings, which have been provided on the major ceremonial dinner in a excellent audiovisual presentation, have been sincerely the spotlight of the assembly and may lengthy be remembered through the attendees. We have been additionally venerated by means of the presence of Dr. Martine Pierre Marie Granier, the great-granddaughter of Pierre Harie. In her deal with on the ceremonial dinner, Dr. Granier supplied numerous pleasant and intimate vignettes relating Pierre Marie, utilizing previous relations files and images. The clinical Committee needs to increase its gratitude to Dr. Granier for including immeasurably to the ancient surroundings of the meeting.

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18) have also noted the form in serum. Our studies indicated a blocked amino terminus which would explain the change in charge; however, the blocking group has not yet been identified. This form is easily detected by isoelectric focusing since it clearly migrates between the major GH 22K and what is thought to be the first deamidated form of the major GH 22K • A common form of GH 22K that is seen in even highly purified preparations of the hormone is an acidic modification that migrates well ahead of the major form during disc electrophoresis at an alkaline pH (19).

Actions of insulin-like growth factors. Annu Rev Physiol 1985; 47:443. 35. Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L, Hintz RL. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 1982; 212:1279. 36. Brazeau P, Guillemin R, Ling N, Van Wyk JJ, Humbel R. Inhibition by somatomedins of growth hormone secretion stimulated by hypothalamiC growth hormone releasing factor (somatocrinin, GRF) on the synthetic peptide hpGRF. Computs Rende Acad Sci (Paris) 1982; 295:651.

Human growth hormone. New York: Plenum Publishing Corporation, 1986. Kostyo JL, Cameron CM, Olson KC, Jones AJS, Pai R-C. Biosynthetic 20-kilodalton methionyl-human growth hormone has diabetogenic and insulin-like activities. Proc Nat Acad Sci USA 1986; 82:4250. Smal J, Closset J, Hennen G, de Meyts P. Receptor binding and insulin-like effects of 22K human growth hormone and its 20K variant in the rat adipocytes. Endocrinology 1986; 118(suppl):122. Schwartz J, Foster CM. Pituitary and recombinant deoxyribonucleic acid-derived human growth hormones alter glucose metabolism in 3T3 adipocytes.

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Acromegaly: A Century of Scientific and Clinical Progress by Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)

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