By Jerzy Choróbski (Eds.)
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It should be supposed then that either the reacting substrate binds Th simultaneously at three sites at least (one of which has an affinity for the thiazole component, the second to the méthylène bridge, and the third to the pyrimidine component of Th), or that the binding to the reacting substrate is effected only through the thiazole and pyrimidine 44 Neurological Problems components of Th (while the méthylène bridge remains not bound to the substrate, playing only the part of a link securing the proper spatial arrange ment of both the active components of Th).
Especially interesting are the results obtained after use of ThMP. It was shown that this compound acts more slowly than Th and ThDP (in summer much quicker than in winter), and instead of an increase in reaction with 46 Neurological Problems a rising dosage, a complete inhibition follows (particularly in Bufo). ThMP, in doses surpassing 60 mg per 10 g of body weight in Bufo, causes no pupillary closure (in Hyla high doses possess an irregular action). Apparent ly, a certain blood level of the compound inhibits the action of the enzyme, splitting off the molecule of orthophosphoric acid from it, and converting it into Th.
J. Mark et E. Feet et sur celui de P. Mollaret, M. Goulon et M. Tournilhac). Conclusions (1) Les paralysies avec hypokaliémie sont des paralysies fonctionnelles et reversibles, de siège périphérique, conditionnées par une hyperpolarisation de membrane d'une certaine durée et liée à une élévation du rapport —. L'atteinte de la contratilité idio-musculaire, l'inexcitabilité électrique de la fibre musculaire et l'absence de troubles sensitifs, suggèrent de situer le processus d'hyperpolarisation surtout au niveau de la fibre musculaire et de la plaque motrice.
Neurological Problems by Jerzy Choróbski (Eds.)