By Martin G. Pomper, Juri G. Gelovani
With molecular imaging turning into one the quickest transforming into themes in scientific faculties, Informa Healthcare provides Molecular Imaging in Oncology, the 1st accomplished reference on molecular imaging in oncology.
Giving clinicians and researchers a better realizing of the present box, this article covers:
- instrumentation and techniques
- cancer imaging
- probe design
- molecular genetic imaging
- cellular processes
- clinical translation
Filled with over 500 photos, of which greater than 50 are in colour, illustrating diagnostic and healing functions of molecular imaging in melanoma, this article outlines all systems for radiologists, radiology physicists, and radiation oncologists in a concise, single-source guide.
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Additional resources for Molecular Imaging in Oncology
2. 3. 4. 5. 6. Self-sufficiency in growth signals Insensitivity to growth-inhibitory (antigrowth) signals Evasion of programmed cell death (apoptosis) Limitless replicative potential Sustained angiogenesis Tissue invasion and metastasis These six capabilities (as schematically presented in Fig. 11) are acquired in cells during tumor development and are perhaps common in all types of human tumors. 18 Dhara Figure 10 Enrichment of the breast cancer stem cells. (A) Metastatic human breast carcinoma cells were freed of contaminating noncancerous (stromal) cells and separated from one another in a fluorescence-activated cell sorter.
The TGFb pathway is disrupted in many cancers in various ways. First, transcriptional downregulation and loss of function mutation of TGFb receptors are common in many cancers. Secondly, the downstream protein Smad4 is eliminated through loss of function mutation of its encoding gene. Thirdly, the genetic deletion or promoter hypermethylation causes downregulation of p15INK4. And finally, loss of function of pRb either by mutation or through sequestration by viral oncoproteins, such as the E7 oncoprotein of human papillomavirus, results in the disruption of this antigrowth pathway as a hallmark of cancer.
Chromosomal translocations: Chromosomal translocation is an important genetic alteration in cancer in which a part of one chromosome is cleaved and integrated into another chromosome. In solid tumors, the translocations are random; there is no site specificity for the break points or point of insertion. On the other hand, liquid tumors such as leukemia and lymphoma generally contain characteristic translocations. For example, in acute promyelocytic leukemia (PML), there is virtually always a characteristic translocation of t(15;17) resulting in the fusion of a retinoic acid receptor gene on chromosome 17 with the PML gene on chromosome 15.
Molecular Imaging in Oncology by Martin G. Pomper, Juri G. Gelovani