By J. K. Aronson (auth.), Norbert Rietbrock, Barry G. Woodcock, Günter Neuhaus (eds.)
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Extra resources for Methods in Clinical Pharmacology: The proceedings of an International Symposium held in Frankfurt/M. 6–8 May 79
45 The parotid gland as an "isolated organ" in vivo- Organ-speci:fic determination of ß- adrenergic stimulation in man G. Schultze-Werninghaus, R. Merget, G. Fachinger, G. Kaiser, D. Palm Zentrum der Inneren Medizin, Abt. für Pneumologie und Zentrum der Pharmakologie Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main This work was supported by a grant from the Deutsche Forschungsgemeinschaft Introduction Effects of ß-sympathomimetic drugs in man can be measured indirectly, e. g.
1977). Evaluations of prison inmate as a subject in drug assessment. Clin. Pharm. , 21, 1-8. Snedecor, G. , and Cochran, W. G. (1967). Stastical Methods. , p. 327. lowa: Ames. Soroko, F. , Mehta, N. , Maxwell, R. , Ferris, R. , and Schroeder, D. H. (1977). Bupropion hydrochloride (dla-t-butylamino-3-chloropropiophenone HCI), a novel antidepressant agent. J. Pharm. , 29,767-770. Swets,]. , Tanner, W. , and Birdsall, T. G. (1961). Decision processes in perception. Psycho!. , 68, 301-340. Wilkinson, R.
Increases of the concentrations of lactate or free fatty acids in blood. A more direct indicator for ß-adrenergic stimulation would be the measurement of increased concentrations of cAMP in plasma. However, such changes would reflect only an overall stimulation of ß-adrenoceptors in the organIsm. It would be desirable, however, to have methods available for determination of organ-specific reactions in response to a ß-adrenergic stimulator as is possible in vitro in isolated organs. It has been suggested by SCHMID et al.
Methods in Clinical Pharmacology: The proceedings of an International Symposium held in Frankfurt/M. 6–8 May 79 by J. K. Aronson (auth.), Norbert Rietbrock, Barry G. Woodcock, Günter Neuhaus (eds.)