By K. Hajós, M.-K. Hajós (auth.), E. Rajka, S. Korossy (eds.)
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Extra resources for Immunological Aspects of Allergy and Allergic Diseases: Volume 5 Clinical Aspects of Allergic Diseases
The antibody is IgE and/or IgG, tissue damage is mediated by antigenantibody complexes (see Chapter 51). In fungal allergy for provocation tests nasal, conjunctival, buccal instillation as well as skin tests with fungal allergens are applied. Prick test in itself has been found insufficient on account of the high number of false negative results as compared with inhalation using Candida albicans antigen [144a]. In our practice skin tests combined with provocation tests have been found suitable for the demonstration of fungal asthma.
The lowered arterial carbon dioxide tension (PaC0 2 ) begins to return to normal, the arterial oxygen tension (Pa0 2 ) falls further, and as the situation worsens the PaC0 2 begins to rise. Hypoxaemia invariably becomes more severe with the rise in PaC0 2, and since hypercapnia develops rapidly in severe asthma, homeostatic mechanisms do 'not adjust the acid-base balance and there is uncompensated respiratory acidosis and acidaemia. The water balance is also changed in bronchial asthma. Changes in the amount of urine fluid retention and oedemas are common symptoms.
House dust, moulds, animal danders, in the production of asthmatic attacks by careful analysis of the patient's history and positive inhalation and skin tests. In some areas there are abundant amounts of air-borne penicillium and aspergillus spores. In Hungary most positive results are obtained with fungi causing dermatomycoses (trichophyton, epidermophyton) as well as alternaria, muoor and rhizopus extracts. Skin tests of the delayed hypersensitivity type and inhalation tests yield in about 50 per cent ofthe cases identical results.
Immunological Aspects of Allergy and Allergic Diseases: Volume 5 Clinical Aspects of Allergic Diseases by K. Hajós, M.-K. Hajós (auth.), E. Rajka, S. Korossy (eds.)