By Ulrich Flogel, Eric Ahrens
ISBN-10: 2222222222
ISBN-13: 9782222222224
ISBN-10: 9814745316
ISBN-13: 9789814745314
ISBN-10: 9814745324
ISBN-13: 9789814745321
Over the previous decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered major clinical curiosity within the biomedical study group as a result of the original homes of fluorinated fabrics and the 19F nucleus. Fluorine has an intrinsically delicate nucleus for MRI. there's negligible endogenous 19F within the physique and hence there is not any heritage sign. Fluorine-containing compounds are perfect tracer labels for a large choice of MRI purposes. furthermore, the chemical shift and nuclear leisure cost may be made attentive to body structure through artistic molecular layout.
This ebook is an interdisciplinary compendium that information state-of-the-art technological know-how and scientific study within the rising box of 19F MRI. Edited via Ulrich Flögel and Eric Ahrens, admired MRI researchers, this ebook will attract investigators all in favour of MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.
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Additional info for Fluorine magnetic resonance imaging
Example text
Limited hardware extensions and essential software enhancements allow the scanner to perform simultaneous transmission and detection of RF signals at two distinct resonant frequencies, in particular at 128 MHz (1H) and 120 MHz (19F). In this scanner architecture, acquisition of the 19F signal can be complemented with real-time assessment of the underlying anatomy as well as physiological motion via the 1H channel without interrupting continuous averaging at the 19F frequency. , the gradient system) remained unchanged.
19F coronary angiography at clinical field strength was demonstrated with minimal background contamination by Neubauer et al. [7]. PFC NPs have also been used as a novel probe for observing vascular leakage in various pathology processes, such as vulnerable atherosclerotic plaque [25] and ischemia-reperfusion kidney injury [26]. Although typically constrained by size within the healthy intact vasculature, PFC NPs can penetrate into inflamed tissues through damaged endothelial barriers, and 19F/1H MRI can be used to quantify vascular leakage by measuring the retained concentration of PFC NPs [27].
Aime S, Carrera C, Delli Castelli D, Crich SG, Terreno E. (2005). Tunable imaging of cells labeled with MRI-PARACEST agents. Angew Chem Int Edit, 44, 1813–1815. Chalmers KH, Kenwright AM, Parker D, Blamire AM. (2011). 19F-lanthanide complexes with increased sensitivity for 19F-MRI: Optimization of the MR acquisition. Magn Reson Med, 66, 931–936. de Vries A, Moonen R, Yildirim M, Langereis S, Lamerichs R, Pikkemaat JA, Baroni S, Terreno E, Nicolay K, Strijkers GJ, Grull H. (2014). Relaxometric studies of gadolinium-functionalized perfluorocarbon nanoparticles for MR imaging.
Fluorine magnetic resonance imaging by Ulrich Flogel, Eric Ahrens
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