Drug Delivery System by Kewal K. Jain (eds.) PDF

By Kewal K. Jain (eds.)

ISBN-10: 1493903624

ISBN-13: 9781493903627

ISBN-10: 1493903632

ISBN-13: 9781493903634

Drug supply structures, moment Edition expands upon the former version with present, distinct equipment and applied sciences to extra learn drug supply. With new chapters on nanobiotechnology recommendations, experimental tools and the medical use for the intrathecal supply of analgesics. Written within the hugely winning equipment in Molecular Biology sequence layout, chapters comprise introductions to their respective themes, lists of the required fabrics and reagents, step by step, with ease reproducible laboratory protocols and tips about troubleshooting and keeping off recognized pitfalls.

Authoritative and useful, Drug supply structures, moment Edition might be priceless for pharmaceutical scientists in addition to good as physicians either within the educational associations and within the industry.

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Extra resources for Drug Delivery System

Sample text

The current status of avidin–biotin systems and their use for pretargeted drug delivery and vector targeting have been reviewed elsewhere [33]. 5 Targeted Delivery of Biologicals with Controlled Release ● Targeting antibodies and therapeutic molecules are administered separately leading to a reduction of drug dose in normal tissues compared with conventional (radio)immunotherapies. ● Introducing avidin gene into specific tissues by local gene transfer, which subsequently can sequester and concentrate considerable amounts of therapeutic ligands.

Good availability and rapid absorption. ● Offer protection against contamination, light, and oxidation. ● Unpleasant flavors are avoided due to content encapsulation. Drug-release rates of orally administered products tend to decrease from the matrix system as a function of time based on the nature and method of preparation. Various approaches to address the problems associated with drug-release mechanisms and release rates use geometric configurations including the cylindrical rod method and the cylindrical donut methods.

It is important to understand the events involved in the movement of surface-bound and extracellular components by endocytosis into the cell. Knowledge of sorting events within the endocytic pathways that govern the intracellular destination and the ultimate fate of the drug is also important. If internalization of the drug is followed by recycling or degradation, no accumulation can occur within the cell. Strategies for regulation of such events can enhance drug delivery. One example is the delivery of genes via receptor-mediated endocytosis in hepatocytes.

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Drug Delivery System by Kewal K. Jain (eds.)

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