Download PDF by C. Braestrup, P. H. Andersen (auth.), Prof. Dr. Svein G.: Clinical Pharmacology in Psychiatry: From Molecular Studies

By C. Braestrup, P. H. Andersen (auth.), Prof. Dr. Svein G. Dahl, Prof. Dr. Lars F. Gram (eds.)

ISBN-10: 3642744303

ISBN-13: 9783642744303

ISBN-10: 364274432X

ISBN-13: 9783642744327

This quantity collects the invited lectures and a few chosen contributions awarded on the fifth foreign assembly on medical Pharmacology in Psychiatry, which used to be held 26-30 June 1988 on the college of Troms0, Norway. The 24 h of sunlight on the northernmost collage on the earth al­ lowed for lengthy, friendly and effective classes. The name of the convention in addition to a few of the themes lined characterize a continuation of 4 prior meetings, the 1st held in Chicago in 1979 and arranged by means of the overdue Earl U sdin and co-workers. the sooner meetings were documented in scientific Pharmacology in Psychiatry, edited by way of E. Usdin (Elsevier, long island, 1981), scientific Pharmacology in Psychiatry. Neuroleptic and Antidepressant study, edited by way of E. Usdin, S. G. Dahl, L. F. Gram and o. Lingjrerde (Macmillan Publishers Ltd., London, 1981), medical Pharmacology in Psychiatry. Bridging the Experimental-Therapeutic hole, edited by way of LF. Gram, E. Usdin, S.G. Dahl, P. Kragh-Sorensen, P. L. Morselli and F. Sjoqvist (Macmillan Publishers Ltd., London, 1983), and medical Pharmacology in Psychiatry. Selectivity in Psychotropic Drug motion - delivers or difficulties? edited through S. G. Dahl, L.F. Gram, S.M. Paul and W.Z. Potter (Psychopharmacology sequence three, Springer, Heidelberg, 1987).

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Could we gain more information from studying ratios of variables than looking at their correlations? 44 W. Z. Potter et al. 3 Ratios: Theoretical Considerations Ratios involve a numerator and denominator and hence necessarily say something about the relationship of two terms. Take, for instance, the ratio of 5HIAA and HV A concentrations in CSF. If one uses a standard twodimensional plot with 5-HIAA on the ordinate and HVA on the abscissa (Fig. 1), it is immediately apparent that the point of intersection can be mathematically described as a distance from the origin, r, which is the hypotenuse of a right triangle with an angle of elevation, a, which is the arc tangent of HV A/5-HIAA.

1983; Davis et al. 1984; Gunnet and Moore 1988). 3), indicating that the regimens were consistently efficient despite the variety of drugs and doses used. The fact that this range of occupancy was maintained throughout the whole monthly interval demonstrates a genuinely stable delivery of neuroleptics to the pharmacological targets in the central nervous system by this route, consistent with pharmacokinetic data (Jergensen 1986). The latter, however, indicate a progressive drop in plasma level concentrations which probably is too small to have significant influence on elevated occupancy rates.

In: Dahl SG, Gram LF, Paul SM, Potter WZ (eds) Clinical pharmacology in psychiatry. Springer, Berlin Heidelberg New York, pp 266-274 Davis JM, Andriukaitis S (1986) The natural course of schizophrenia and effective maintenance drug treatment. J Clin PsychopharmacoI6:25-1 05 Davis JM, Vogel C, Gibbons R, Parkovic I, Zhang M (1984) Pharmacoendocrinology of schizophrenia. In: Brown GM et al. (eds) Neuroendocrinology and psychiatric disorder. Raven, NewYork,pp 29-53 Farde L, Hall H, Ehrin E, Sedvall G (1986) Quantitative analysis ofD2 dopamine receptor bindi~g in the living human brain by PET.

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Clinical Pharmacology in Psychiatry: From Molecular Studies to Clinical Reality by C. Braestrup, P. H. Andersen (auth.), Prof. Dr. Svein G. Dahl, Prof. Dr. Lars F. Gram (eds.)

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