By Joseph Sweeney M.D., Andrew Heaton M.D. (auth.)
Joseph Sweeney, Andrew Heaton he presence of allogeneic leukocytes in blood items got little T consciousness until eventually the mid-1950s whilst those "passenger" cells have been im plicated within the etiology of febrile transfusion reactions, and early strate gies in keeping with centrifugation have been built to impression their elimination. In fresh a long time and, really some time past 5 years, there was an accumulation of literature implicating leukocytes in a large choice of bad reactions to blood transfusion. White cells are the least a number of of the mobile parts in blood and ratios of white cells to platelets and white cells to pink cells are ap proximately 1:15 to 1:1000 respectively. This ratio is maintained in complete blood, yet can be altered a bit within the technique of part prepara tion. Any construction or processing step which deliberately decreases this ratio will bring about a product which are defined as white telephone depleted. It has, even though, develop into extra universal to outline the end result as a residual white phone content material, instead of a reduce in mobile ratios, even though the latter makes extra experience on theoretical grounds, when you consider that deple tion of white cells has to be installed the context of any unintended lack of pink cells or platelets. the result of this intentional processing step, accordingly, is mostly expressed because the residual absolute variety of white cells or because the measure of distinction in white mobilephone content material, the latter expressed as both a percent switch or as a logarithmic reduction.
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G. Landes Company. 30 INTRODUCTION The growing knowledge of transfusion medicine has caused an increasing interest in the possibilities of separating blood into its pure components. Blood is composed of plasma containing factors such as the coagulation and fibrinolytic proteins, red blood cells, leukocytes and platelets. To separate blood components differential centrifugation, sedimentation, washing, freezing and thawing and filtration have all been evaluated. 1 ·~ The application of filtration is attractive because it is relatively easy to perform under sterile conditions.
To separate blood components differential centrifugation, sedimentation, washing, freezing and thawing and filtration have all been evaluated. 1 ·~ The application of filtration is attractive because it is relatively easy to perform under sterile conditions. Not only plasma but cellular components can be separated from the cells and purified from each other. Lm in order to prevent clots and debris from entering the blood circulation of the recipient. Lm were introduced to prevent respiratory complications after (massive) transfusions of whole blood.
Not only plasma but cellular components can be separated from the cells and purified from each other. Lm in order to prevent clots and debris from entering the blood circulation of the recipient. Lm were introduced to prevent respiratory complications after (massive) transfusions of whole blood. 6 It was suggested that disintegrating leukocytes, together with platelets, fibrin and red cells formed microaggregates in stored blood. After transfusion the microaggregates obstruct pulmonary capillaries and thus induce respiratory distress.
Clinical Benefits of Leukodepleted Blood Products by Joseph Sweeney M.D., Andrew Heaton M.D. (auth.)