By Michael T. McMahon, Assaf A. Gilad, Jeff W.M. Bulte, Peter C.M. van Zijl
Chemical alternate saturation move (CEST) imaging is a strong magnetic resonance imaging (MRI) approach with designated distinction positive factors. This expertise permits the amplified detection of nM to mM concentrations of small molecules and macromolecules (including these enthusiastic about biologic pathways) via selective radio frequency labeling of quickly replacing protons current at the molecules of curiosity. simply because this labeling is frequency established, CEST brokers have merits over the extra validated water relaxation–based distinction brokers, making them extra just like optical imaging brokers and permitting the detection of a number of brokers independently inside an anatomical sector for a variety of molecular imaging purposes. The speedy growth that CEST imaging has visible during the last 15 years due to the fact its unique discovery in 2000 had created a necessity for a graduate-level guide describing all facets of preclinical, translational, and medical CEST imaging, and this can be the 1st devoted textbook protecting all of them.
The publication includes 19 chapters that conceal the basic ideas of saturation move, the foremost gains of CEST brokers allowing construction of imaging distinction, and the sensible facets of photo acquisition and imaging post-processing schemes adapted to the categorical software. during this booklet, the leaders who constructed CEST imaging on the 5 key websites current a distinct, illustrated, ancient point of view from the preliminary saturation move nuclear magnetic resonance (NMR) experiments played within the Sixties in Stockholm, Sweden, defined by means of Sture Forsén, to the paintings performed on integrating the fundamental ideas of CEST into imaging within the usa and Italy, lined by means of Robert Balaban, Dean Sherry, Silvio Aime, and Peter van Zijl. The editors, Drs. Michael T. McMahon, Assaf A. Gilad, Jeff W. M. Bulte, and Peter C. M. van Zijl, are pioneers constructing this box on the Johns Hopkins college tuition of drugs and the Kennedy Krieger Institute.
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Additional info for Chemical Exchange Saturation Transfer Imaging: Advances and Applications
Altogether, the limitations of Gd-based agents prompted chemists to look at other routes to aﬀect the contrast in MR images.
Application of phasemodulated CLEAN chemical EXchange spectroscopy (CLEANEX-PM) to detect water-protein proton exchange and intermolecular NOEs. J. Am. Chem. , 1997; 119(26): 6203–6204. 7. Mori S, Abeygunawardana C, Johnson MO, and van Zijl PCM. Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation. J. Magn. Reson. Ser. , 1995; 108(1): 94–98. 8. Mori S, Eleﬀ SM, Pilatus U, Mori N, and van Zijl PCM.
Based on my vague familiarity with earlier magnetization transfer contrast (MTC) work on semi-solid tissues, I had somehow understood from the Balaban poster that it was necessary to have large immobile molecules to saturate the molecular backbone protons and then have a fast nuclear overhauser enhancement (NOE) transfer through the backbone and to the exchangeable protons, followed by exchange to water. So I asked Tsang-Lin to look at glycogens of large molecular weight, which should have fast spin diﬀusion and backbone protons in close contact with a large number of exchangeable groups.
Chemical Exchange Saturation Transfer Imaging: Advances and Applications by Michael T. McMahon, Assaf A. Gilad, Jeff W.M. Bulte, Peter C.M. van Zijl