By Charles G. D. Brook, Peter E. Clayton, Rosalind S. Brown, M. O. Savage
This treatise of paediatric endocrinology, now in its moment version, covers either pathophysiological and physiological facets of the topic, with a unique emphasis on medical administration. Written by means of a multi-author workforce of overseas contrast, the ebook is a worthy reference for common departments of paediatrics and for endocrinologists facing childrens. during this moment version which has been completely revised and with a ordinarily new authorship, a lot emphasis has been put on more recent elements of endocrine body structure that are mirrored in scientific perform.
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Additional resources for Brook's Clinical Pediatric Endocrinology, 5th Edition
The intensity of the emitted signal on each spot permits calculation of the ratios of each RNA that binds to the respective probe. can be detected easily (see Plate 1, facing p. 148). This allows staining of speciﬁc DNA segments in situ on a metaphase chromosome spread or within a cell nucleus. FISH is widely used for diagnostic cytogenetic analyses and in the mapping of genes. FISH probes can consist of a single contiguous genomic sequence or a mixture of two or multiple probes. g. a chromosome arm, or whole chromosomes.
Human DNA consists of about 3 billion basepairs (bp) of DNA per haploid genome contained in the 23 chromosomes. The smallest chromosome (chromosome 21) contains approximately 50 million bp, the largest (chromosome 1) 250 million bp. The human genome is estimated to contain about 30 000 – 40 000 genes. This number is smaller than the original estimates (up to 100 000 genes), which were derived from the large diversity of proteins. This observation indicates that alternative splicing of genes is an important mechanism generating protein diversity.
Substitutions are called transitions if a purine is replaced by another purine base (A to G) or if a pyrimidine is replaced by another pyrimidine (C to T). Changes from a purine to a pyrimidine or vice versa are referred to as transversions. Certain DNA sequences, such as successive pyrimidines or CG dinucleotides, are particularly susceptible to mutagenesis. Therefore, certain types of mutations (C to T or G to A) are relatively common. Moreover, the nature of the genetic code results in overrepresentation of certain amino acid substitutions.
Brook's Clinical Pediatric Endocrinology, 5th Edition by Charles G. D. Brook, Peter E. Clayton, Rosalind S. Brown, M. O. Savage