By H. Kalimo, L. Paljärvi, Y. Olsson, B. K. Siesjö (auth.), Professor Dr. Klaus Wiedemann, Professor Dr. Siegfried Hoyer (eds.)
ISBN-10: 3642691757
ISBN-13: 9783642691751
ISBN-10: 3642691773
ISBN-13: 9783642691775
Significant development has potentially been made within the box of cere bral safety in comparison to previous centuries, as lately reviewed via Elisabeth Frost (6). She cites the ideas for deal with ment of mind trauma by way of Areteus, a Greek surgeon of the second one century A. D. He expressed really modem perspectives with reference to the necessity for suggested motion contemplating problems that keep on with even minor indicators. He steered burr holes for evacuation of hema toma in seizures, using diuretics and, such a lot apparently, additionally hypothermia. German surgeons of the seventeenth century had little extra to supply than prescriptions of which the best constituent was once alcohol (10). therefore, Sir Astley Cooper used to be most likely the subsequent health practitioner to make noteworthy contributions while advising using leeches to the temporal artery and different technique of bleeding in stead of surgical intervention in situations of raised intracranial strain (loc. cit. 6). even if our wisdom has drastically increased over the past 20 years, wide discussions have resulted in purely few conclusions. Promising effects from animal reports have been translated to medical take a seat uations basically to yield arguable and infrequently complicated effects. because the observations of Brierly (5) on ischemic mobilephone harm, im proved details on structural points, most likely even concerning concomitant biochemical experiences, should still let the validity of thera peutic strategies to be demonstrated. Investigations on cerebral ischemia have ended in the differentiation of synaptic transmission failure and membrane failure.
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Extra resources for Brain Protection: Morphological, Pathophysiological and Clinical Aspects
Sample text
977) A technique for recording local blood flow and neuronal activity with a single microelectrode. PflUgers Arch 369:183-186 11. Scholz W (! 953) Selective neuronal necrosis and its topistic patterns in hypoxemia and oligemia. J Neuropath Exp Neurol 12:2lt9-261 12. Sharbrough FW, Messick JM, Sundt TM jr (! 973) Correlation of continuous electroencephalograms with cerebral blood flow measurements during carotid endarterectomy. Stroke 1t:671t-683 13. Spielmeyer W (! 922) Histopathologie des Nervensystems.
Drugs Experiment Clin Res 7:1-10 3. Ashton 0, Wauquier A (I 979) Effects of some anti-epileptic, neuroleptic and gabaminergic drugs on convulsions induced in rats by injection of D,L-allylglycine. Pharmacol Biochem Behav 11:221-226 4. Ashton 0, Van Reempts J, Wauquier A (1981) Behavioral, electroencephalographic and histological study of the protective effect of etomidate against histotoxic anoxia produced by cyanide. Arch Int Pharmacodyn Therap 254: 196-213 5. Avery S, Crockard A, Ross Russell R (1982) Reperfusion oedema in gerbils.
In one series, the extracellular K+ concentration in the brain cortex was monitored by a surface potassium electrode (4) and the effect of 32 thiopental 40 mg/kg and of lidocaine 160 mg/kg on the rate of rise in the surface K+ concentration following circulatory arrest was studied at brain temperatures of 37, 28 and 180 C. In a second series, cerebral blood flow and oxygen and glucose uptake (CMR0 2 and CMRgl) were measured by the sagittal sinus outflow method of Rapela et al. (13) and Michenfelder et aI.
Brain Protection: Morphological, Pathophysiological and Clinical Aspects by H. Kalimo, L. Paljärvi, Y. Olsson, B. K. Siesjö (auth.), Professor Dr. Klaus Wiedemann, Professor Dr. Siegfried Hoyer (eds.)
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