By Neuroscience Education Institute
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Additional info for Understanding and Managing the Pieces of Major Depressive Disorder
Major depressive disorder (MDD) may not be inherited per se, but risk for MDD may be inherited as a series of risk genes (indicated here as P, Q, and R). Whether a risk manifests itself as overt MDD may depend upon exposure of genetically vulnerable circuits to stress. In the presence of major stressors, circuits rendered vulnerable by risk genes to developing inefficient information processing under stress may break down, and if sufficient symptoms prevail, MDD may result. indd 34 9/30/2009 12:26:48 PM Chapter 2 Treatments for Depression Today’s psychopharmacologist has a vast array of medications to choose from when treating major depressive disorder, and depending on their mechanism of action some medications may be more useful than others for various individuals.
B) NETs actually have higher affinity for DA than they do for NE! Thus, in the PFC, NETs inactivate both NE and DA, and blockade of NETs will lead to an increase in both NE and DA levels. 17. S. market, and has become one of the most frequently prescribed antidepressants on the market. Venlafaxine has varying degrees of inhibition of norepinephrine reuptake (NRI) depending on the dose, whereas serotonin reuptake inhibition (SRI) is moderately potent and present at all approved doses. Venlafaxine is a substrate for CYP450 2D6, which converts it to the active metabolite desvenlafaxine.
5HT can regulate DA release directly or indirectly. (A) When 5HT binds to 5HT2A receptors on DA neurons or on GABA neurons, DA release is decreased directly or via inhibition through GABA release, respectively. (B) Upon binding to 5HT1A receptors, 5HT causes inhibition of its own release. A lack of 5HT results in disinhibition of DA release, and therefore increased DA output. 32. 5HT2C receptors inhibit both dopamine (DA) and norepinephrine (NE) release. This occurs when serotonin (5HT) binds to 5HT2C receptors on GABA interneurons in the brainstem and excites them, causing release of the inhibitory neurotransmitter GABA onto both NE (on the left) and DA neurons (on the right).
Understanding and Managing the Pieces of Major Depressive Disorder by Neuroscience Education Institute